Virulence regulation with Venus flytrap domains: structure and function of the periplasmic moiety of the sensor-kinase BvgS.

Two-component systems (TCS) represent major signal-transduction pathways for adaptation to environmental conditions, and regulate many aspects of bacterial physiology. In the whooping cough agent Bordetella pertussis, the TCS BvgAS controls the virulence regulon, and is therefore critical for pathog...

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Main Authors: Elian Dupré, Julien Herrou, Marc F Lensink, René Wintjens, Alexey Vagin, Andrey Lebedev, Sean Crosson, Vincent Villeret, Camille Locht, Rudy Antoine, Françoise Jacob-Dubuisson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1004700