Do randomized clinical trials with inadequate blinding report enhanced placebo effects for intervention groups and nocebo effects for placebo groups? A protocol for a meta-epidemiological study of PDE-5 inhibitors

Do randomized clinical trials with inadequate blinding report enhanced placebo effects for intervention groups and nocebo effects for placebo groups? A protocol for a meta-epidemiological study of PDE-5 inhibitors

<p>Abstract</p> <p>Background</p> <p>Patients’ expectations of treatment effects may contribute to positive (placebo) and negative (nocebo) outcomes. The effect of patient expectations may be pronounced in subjectively assessed conditions, such as male erectile dysfunct...

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Bibliographic Details
Main Authors: Feys Frederik, Bekkering Geertruida E, Singh Kavita, Devroey Dirk
Format: Article
Language:English
Published: BMC 2012-11-01
Series:Systematic Reviews
Subjects:
Bias
Blinding
Expectancy
Nocebo
Phosphodiesterase-5 inhibitor
Placebo
Randomized controlled trial
Online Access:http://www.systematicreviewsjournal.com/content/1/1/54

Internet

http://www.systematicreviewsjournal.com/content/1/1/54

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