Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics.

Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics.

The development of plasma biomarkers could facilitate early detection, risk assessment and therapeutic monitoring in Alzheimer's disease (AD). Alterations in ceramides and sphingomyelins have been postulated to play a role in amyloidogensis and inflammatory stress related neuronal apoptosis; ho...

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Bibliographic Details
Main Authors: Xianlin Han, Steve Rozen, Stephen H Boyle, Caroline Hellegers, Hua Cheng, James R Burke, Kathleen A Welsh-Bohmer, P Murali Doraiswamy, Rima Kaddurah-Daouk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3136924?pdf=render

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http://europepmc.org/articles/PMC3136924?pdf=render

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