stageR: a general stage-wise method for controlling the gene-level false discovery rate in differential expression and differential transcript usage

stageR: a general stage-wise method for controlling the gene-level false discovery rate in differential expression and differential transcript usage

Abstract RNA sequencing studies with complex designs and transcript-resolution analyses involve multiple hypotheses per gene; however, conventional approaches fail to control the false discovery rate (FDR) at gene level. We propose stageR, a two-stage testing paradigm that leverages the increased po...

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Bibliographic Details
Main Authors: Koen Van den Berge, Charlotte Soneson, Mark D. Robinson, Lieven Clement
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Genome Biology
Subjects:
RNA-sequencing
Stage-wise testing
Differential transcript usage
Differential expression
Online Access:http://link.springer.com/article/10.1186/s13059-017-1277-0

Internet

http://link.springer.com/article/10.1186/s13059-017-1277-0

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