A Computational Model for the AMPA Receptor Phosphorylation Master Switch Regulating Cerebellar Long-Term Depression.

A Computational Model for the AMPA Receptor Phosphorylation Master Switch Regulating Cerebellar Long-Term Depression.

The expression of long-term depression (LTD) in cerebellar Purkinje cells results from the internalisation of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs) from the postsynaptic membrane. This process is regulated by a complex signalling pathway involving sustained protein...

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Bibliographic Details
Main Authors: Andrew R Gallimore, A Radu Aricescu, Michisuke Yuzaki, Radu Calinescu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4726815?pdf=render

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http://europepmc.org/articles/PMC4726815?pdf=render

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