Elevated expression of serotonin 5-HT2A receptors in the rat ventral tegmental area enhances vulnerability to the behavioral effects of cocaine

Elevated expression of serotonin 5-HT2A receptors in the rat ventral tegmental area enhances vulnerability to the behavioral effects of cocaine

The dopamine mesocorticoaccumbens pathway which originates in the ventral tegmental area (VTA) and projects to the nucleus accumbens and prefrontal cortex is a circuit important in mediating the actions of psychostimulants. The function of this circuit is modulated by the actions of serotonin (5-HT)...

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Bibliographic Details
Main Authors: David V. Herin, Marcy J. Bubar, Patricia K. Seitz, Mary L. Thomas, Gilbert R. Hillman, Yevgeniya I. Tarasenko, Ping eWu, Kathryn A. Cunningham
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-02-01
Series:Frontiers in Psychiatry
Subjects:
Cocaine
Serotonin
locomotor activity
Psychostimulants
5-HT2A receptor
AAV vectors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00002/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00002/full

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