Inhibition of DNA Methylation With Zebularine Alters Lipopolysaccharide-Induced Sickness Behavior and Neuroinflammation in Mice

Inhibition of DNA Methylation With Zebularine Alters Lipopolysaccharide-Induced Sickness Behavior and Neuroinflammation in Mice

Activity of DNA methyltransferases (DNMTs), the enzymes that catalyze DNA methylation, is dynamically regulated in the brain. DNMT inhibitors alter DNA methylation globally in the brain and at individual neural plasticity-associated genes, but how DNMT inhibitors centrally influence lipopolysacchari...

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Bibliographic Details
Main Authors: Stephanie M. Matt, Jalisa D. Zimmerman, Marcus A. Lawson, Angela C. Bustamante, Monica Uddin, Rodney W. Johnson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Neuroscience
Subjects:
microglia
neuroimmunology
Il-1β
DNMT inhibitor
DNA methylation
mouse models
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00636/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00636/full

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