Hypoxia promotes colorectal cancer cell migration and invasion in a SIRT1-dependent manner

Hypoxia promotes colorectal cancer cell migration and invasion in a SIRT1-dependent manner

Abstract Background Hypoxic microenvironments play a significant role in the progression of colorectal cancer (CRC). Silencing information regulator 1 (SIRT1), a class III histone deacetylase, modulates the multiple biological behaviors of cancer. However, its role in CRC remains unclear. This study...

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Bibliographic Details
Main Authors: Shentong Yu, Ru Zhou, Tong Yang, Shuang Liu, Zhuqing Cui, Qing Qiao, Jing Zhang
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Cancer Cell International
Subjects:
Hypoxia
SIRT1
EGR1
Colorectal cancer
Migration
Invasion
Online Access:http://link.springer.com/article/10.1186/s12935-019-0819-9

Internet

http://link.springer.com/article/10.1186/s12935-019-0819-9

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