The membrane-spanning domain of gp41 plays a critical role in intracellular trafficking of the HIV envelope protein

<p>Abstract</p> <p>Background</p> <p>The sequences of membrane-spanning domains (MSDs) on the gp41 subunit are highly conserved among many isolates of HIV-1. The GXXXG motif, a potential helix-helix interaction motif, and an arginine residue (rare in hydrophobic MSDs) a...

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Bibliographic Details
Main Authors: Kondo Naoyuki, Long Yufei, Curran A Rachael, Miyauchi Kosuke, Iwamoto Aikichi, Engelman Donald M, Matsuda Zene
Format: Article
Language:English
Published: BMC 2010-11-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/7/1/95