Hardy-Weinberg Equilibrium in the Large Scale Genomic Sequencing Era

Hardy-Weinberg Equilibrium in the Large Scale Genomic Sequencing Era

Hardy-Weinberg Equilibrium (HWE) is used to estimate the number of homozygous and heterozygous variant carriers based on its allele frequency in populations that are not evolving. Deviations from HWE in large population databases have been used to detect genotyping errors, which can result in extrem...

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Bibliographic Details
Main Authors: Nikita Abramovs, Andrew Brass, May Tassabehji
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Genetics
Subjects:
Hardy-Weinberg Equilibrium
heterozygote advantage
gnomAD
association studies in genetics
recessive inheritance
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00210/full

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https://www.frontiersin.org/article/10.3389/fgene.2020.00210/full

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