The multikinase inhibitor Sorafenib displays significant antiproliferative effects and induces apoptosis via caspase 3, 7 and PARP in B- and T-lymphoblastic cells

The multikinase inhibitor Sorafenib displays significant antiproliferative effects and induces apoptosis via caspase 3, 7 and PARP in B- and T-lymphoblastic cells

<p>Abstract</p> <p>Background</p> <p>Targeted therapy approaches have been successfully introduced into the treatment of several cancers. The multikinase inhibitor Sorafenib has antitumor activity in solid tumors and its effects on acute lymphoblastic leukemia (ALL) cel...

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Bibliographic Details
Main Authors: Boldt Sonja, Fuellen Georg, Glass Aenne, Etro Daniela, Lange Sandra, Amoroso Francesca, Sawitzky Mandy, Ruck Sabine, Dahlhaus Meike, Schult Catrin, Wolkenhauer Olaf, Neri Luca, Freund Mathias, Junghanss Christian
Format: Article
Language:English
Published: BMC 2010-10-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/10/560

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http://www.biomedcentral.com/1471-2407/10/560

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