The Effect of Size, Maturation, Global Asphyxia, Cerebral Ischemia, and Therapeutic Hypothermia on the Pharmacokinetics of High-Dose Recombinant Erythropoietin in Fetal Sheep

The Effect of Size, Maturation, Global Asphyxia, Cerebral Ischemia, and Therapeutic Hypothermia on the Pharmacokinetics of High-Dose Recombinant Erythropoietin in Fetal Sheep

<b> </b>High-dose human recombinant erythropoietin (rEPO) is a promising potential neuroprotective treatment in preterm and full-term neonates with hypoxic-ischemic encephalopathy (HIE). There are limited data on the pharmacokinetics of high-dose rEPO in neonates. We examined the effects...

Full description

Bibliographic Details
Main Authors: Simerdeep K. Dhillon, Guido Wassink, Christopher A. Lear, Joanne O. Davidson, Nicholas H.G. Holford, Alistair J. Gunn, Laura Bennet
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
erythropoietin
pharmacokinetics
fetal sheep
allometric size scaling
maturation of elimination
asphyxia
Online Access:https://www.mdpi.com/1422-0067/21/9/3042

Internet

https://www.mdpi.com/1422-0067/21/9/3042

Similar Items