Fc Gamma Receptors and Complement Component 3 Facilitate Anti-fVIII Antibody Formation

Fc Gamma Receptors and Complement Component 3 Facilitate Anti-fVIII Antibody Formation

Anti-factor VIII (fVIII) alloantibodies, which can develop in patients with hemophilia A, limit the therapeutic options and increase morbidity and mortality of these patients. However, the factors that influence anti-fVIII antibody development remain incompletely understood. Recent studies suggest t...

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Bibliographic Details
Main Authors: Patricia E. Zerra, Connie M. Arthur, Satheesh Chonat, Cheryl L. Maier, Amanda Mener, Sooncheon Shin, Jerry William L. Allen, W. Hunter Baldwin, Courtney Cox, Hans Verkerke, Ryan P. Jajosky, Christopher A. Tormey, Shannon L. Meeks, Sean R. Stowell
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
hemophilia
inhibitors
Fc gamma receptors
complement component 3
alloimmunization
humoral immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00905/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00905/full

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