Selective estrogen receptor modulators (SERMs) affect cholesterol homeostasis through the master regulators SREBP and LXR

Selective estrogen receptor modulators (SERMs) affect cholesterol homeostasis through the master regulators SREBP and LXR

Selective estrogen receptor modulators (SERMs) are nonsteroidal drugs that display an estrogen‐agonist or estrogen‐antagonist effect depending on the tissue targeted. SERMs have attracted great clinical interest for the treatment of several pathologies, most notably breast cancer and osteoporosis. T...

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Bibliographic Details
Main Authors: María E. Fernández-Suárez, Lidia Daimiel, Gemma Villa-Turégano, María Vázquez Pavón, Rebeca Busto, Joan C. Escolà-Gil, Frances M. Platt, Miguel A. Lasunción, Javier Martínez-Botas, Diego Gómez-Coronado
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Tamoxifen
Raloxifene
Toremifene
SREBP
LXR
Cholesterol
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221006533

Internet

http://www.sciencedirect.com/science/article/pii/S0753332221006533

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