Three-component synthesis of C2F5-substituted pyrazoles from C2F5CH2NH2·HCl, NaNO2 and electron-deficient alkynes

Three-component synthesis of C2F5-substituted pyrazoles from C2F5CH2NH2·HCl, NaNO2 and electron-deficient alkynes

A one-pot reaction between C2F5CH2NH2·HCl, NaNO2 and electron-deficient alkynes gives C2F5-substituted pyrazoles in excellent yields. The transformation smoothly proceeds in dichloromethane/water, tolerates the presence of air, and requires no purification of products by column chromatography. Mecha...

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Bibliographic Details
Main Author:	Pavel K. Mykhailiuk
Format:	Article
Language:	English
Published:	Beilstein-Institut 2015-01-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	cycloaddition fluorine pentafluoroethyl group pentafluoroethyldiazomethane pyrazole
Online Access:	https://doi.org/10.3762/bjoc.11.3

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