Three-component synthesis of C2F5-substituted pyrazoles from C2F5CH2NH2·HCl, NaNO2 and electron-deficient alkynes

Three-component synthesis of C2F5-substituted pyrazoles from C2F5CH2NH2·HCl, NaNO2 and electron-deficient alkynes

A one-pot reaction between C2F5CH2NH2·HCl, NaNO2 and electron-deficient alkynes gives C2F5-substituted pyrazoles in excellent yields. The transformation smoothly proceeds in dichloromethane/water, tolerates the presence of air, and requires no purification of products by column chromatography. Mecha...

Full description

Bibliographic Details
Main Author: Pavel K. Mykhailiuk
Format: Article
Language:English
Published: Beilstein-Institut 2015-01-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
cycloaddition
fluorine
pentafluoroethyl group
pentafluoroethyldiazomethane
pyrazole
Online Access:https://doi.org/10.3762/bjoc.11.3

Internet

https://doi.org/10.3762/bjoc.11.3

Similar Items