Protective effect of simvastatin in the cyclophosphamide-induced hemohrragic cystitis in rats Efeito protetor da sinvastatina na cistite hemorrágica induzida pela ciclofosfamida em ratos

Protective effect of simvastatin in the cyclophosphamide-induced hemohrragic cystitis in rats Efeito protetor da sinvastatina na cistite hemorrágica induzida pela ciclofosfamida em ratos

PURPOSE: Cyclophosphamide (CYP) is an antineoplastic agent used for the treatment of many neoplastic and inflammatory diseases. Hemorrhagic cystitis is a frequent side effect of CYP. Several studies show that simvastatin has important pleiotropic (anti-inflammatory and immunomodulatory) effects. The...

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Bibliographic Details
Main Authors: Anna Carolina Batista Dantas, Francisco Fábio de Araújo Batista-Júnior, Larissa Freitas Macedo, Mariana Noronha Castro Mendes, Ítalo Medeiros Azevedo, Aldo Cunha Medeiros
Format: Article
Language:English
Published: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2010-02-01
Series:Acta Cirurgica Brasileira
Subjects:
Ciclofosfamida
Cistite
Sinvastatina
Inflamação
Citocina
Ratos
Cyclophosphamide
Cystitis
Simvastatin
Inflammation
Cytokine
Rats
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502010000100011

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502010000100011

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