Rapid Viral Diagnosis of Orthopoxviruses by Electron Microscopy: Optional or a Must?

Diagnostic electron microscopy (DEM) was an essential component of viral diagnosis until the development of highly sensitive nucleic acid amplification techniques (NAT). The simple negative staining technique of DEM was applied widely to smallpox diagnosis until the world-wide eradication of the hum...

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Bibliographic Details
Main Authors: Hans R. Gelderblom, Dick Madeley
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Viruses
Subjects:
Online Access:http://www.mdpi.com/1999-4915/10/4/142