PAR-4/Ca2+-calpain pathway activation stimulates platelet-derived microparticles in hyperglycemic type 2 diabetes

PAR-4/Ca2+-calpain pathway activation stimulates platelet-derived microparticles in hyperglycemic type 2 diabetes

Abstract Background Patients with type 2 diabetes (T2DM) have a prothrombotic state that needs to be fully clarified; microparticles (MPs) have emerged as mediators and markers of this condition. Thus, we investigate, in vivo, in T2DM either with good (HbA1c ≤ 7.0%; GGC) or poor (HbA1c > 7.0%; PG...

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Bibliographic Details
Main Authors: Alessandra Giannella, Giulio Ceolotto, Claudia Maria Radu, Arianna Cattelan, Elisabetta Iori, Andrea Benetti, Fabrizio Fabris, Paolo Simioni, Angelo Avogaro, Saula Vigili de Kreutzenberg
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Cardiovascular Diabetology
Subjects:
Platelet activation
Extracellular vesicles
NF-kB
Glycated hemoglobin
THP-1 transformed macrophages
Online Access:https://doi.org/10.1186/s12933-021-01267-w

Internet

https://doi.org/10.1186/s12933-021-01267-w

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