MLH1 Deficiency Down-Regulates TLR4 Expression in Sporadic Colorectal Cancer

MLH1 Deficiency Down-Regulates TLR4 Expression in Sporadic Colorectal Cancer

Patients with mismatch repair (MMR)-deficient colorectal cancer (CRC) have a more favorable prognosis than patients with tumors with intact MMR. In order to obtain further insights on the reasons for this different outcome, we investigated the interplay between MMR genes and TLR4/MyD88 signaling. Th...

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Bibliographic Details
Main Authors: Melania Scarpa, Cesare Ruffolo, Andromachi Kotsafti, Fabio Canal, Francesca Erroi, Silvia Basato, Lucia Dall’Agnese, Alain Fiorot, Anna Pozza, Paola Brun, Nicolò Bassi, Angelo Dei Tos, Carlo Castoro, Ignazio Castagliuolo, Marco Scarpa
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
colorectal cancer
TLR4
MLH1
mismatch
innate immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.624873/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.624873/full

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