Cellular Senescence as a Target in Cancer Control

Somatic cells show a spontaneous decline in growth rate in continuous culture. This is not related to elapsed time but to an increasing number of population doublings, eventually terminating in a quiescent but viable state termed replicative senescence. These cells are commonly multinucleated and do...

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Bibliographic Details
Main Authors: Mar Vergel, Juan J. Marin, Purificacion Estevez, Amancio Carnero
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Journal of Aging Research
Online Access:http://dx.doi.org/10.4061/2011/725365