Human CD4+ T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro

Human CD4+ T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro

Abstract Background The brain barriers establish compartments in the central nervous system (CNS) that significantly differ in their communication with the peripheral immune system. In this function they strictly control T-cell entry into the CNS. T cells can reach the CNS by either crossing the end...

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Bibliographic Details
Main Authors: Hideaki Nishihara, Sasha Soldati, Adrien Mossu, Maria Rosito, Henriette Rudolph, William A. Muller, Daniela Latorre, Federica Sallusto, Mireia Sospedra, Roland Martin, Hiroshi Ishikawa, Tobias Tenenbaum, Horst Schroten, Fabien Gosselet, Britta Engelhardt
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Fluids and Barriers of the CNS
Subjects:
Blood–brain barrier
Blood-cerebrospinal fluid barrier
T-cell migration
Adhesion molecule
Multiple sclerosis
Online Access:https://doi.org/10.1186/s12987-019-0165-2

Internet

https://doi.org/10.1186/s12987-019-0165-2

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