Nitrous oxide as a putative novel dual-mechanism treatment for bipolar depression: Proof-of-concept study design and methodology

Nitrous oxide as a putative novel dual-mechanism treatment for bipolar depression: Proof-of-concept study design and methodology

Introduction: Depressive symptoms predominate in the course of bipolar disorder (BD) and there is an urgent need to evaluate novel application of repurposed compounds that act on pre-specified treatment targets. Several lines of reasoning suggest that nitrous oxide (N2O) is an ideal medication to st...

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Bibliographic Details
Main Authors: Mikaela K. Dimick, Danielle Omrin, Bradley J. MacIntosh, Rachel H.B. Mitchell, Daniel Riegert, Anthony Levitt, Ayal Schaffer, Susan Belo, John Iazzetta, Garfield Detzler, Mabel Choi, Stephen Choi, Beverley A. Orser, Benjamin I. Goldstein
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Contemporary Clinical Trials Communications
Subjects:
Nitrous oxide
Bipolar depression
Novel therapeutics
Cerebral blood flow
Online Access:http://www.sciencedirect.com/science/article/pii/S2451865420300843

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http://www.sciencedirect.com/science/article/pii/S2451865420300843

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