Cell-to-Cell Spreading of HIV-1 in Myeloid Target Cells Escapes SAMHD1 Restriction

Cell-to-Cell Spreading of HIV-1 in Myeloid Target Cells Escapes SAMHD1 Restriction

We demonstrate that HIV-1 uses a common two-step cell-to-cell fusion mechanism for massive virus transfer from infected T lymphocytes and dissemination to myeloid target cells, including dendritic cells and macrophages as well as osteoclasts. This cell-to-cell infection process bypasses the restrict...

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Bibliographic Details
Main Authors: Maorong Xie, Héloïse Leroy, Rémi Mascarau, Marie Woottum, Maeva Dupont, Camille Ciccone, Alain Schmitt, Brigitte Raynaud-Messina, Christel Vérollet, Jérôme Bouchet, Lucie Bracq, Serge Benichou
Format: Article
Language:English
Published: American Society for Microbiology 2019-11-01
Series:mBio
Subjects:
hiv-1
samhd1
cell fusion
myeloid cells
virus spreading
Online Access:https://doi.org/10.1128/mBio.02457-19

Internet

https://doi.org/10.1128/mBio.02457-19

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