Identification of a Broad-Spectrum Viral Inhibitor Targeting a Novel Allosteric Site in the RNA-Dependent RNA Polymerases of Dengue Virus and Norovirus

Identification of a Broad-Spectrum Viral Inhibitor Targeting a Novel Allosteric Site in the RNA-Dependent RNA Polymerases of Dengue Virus and Norovirus

All RNA viruses encode the RNA-dependent RNA polymerase (RdRp) which replicates and transcribes viral RNA. This essential viral enzyme does not exist in mammalian cells, thus presents a main target for the development of antiviral drugs with potential pan-antiviral activity. In this study, we take a...

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Bibliographic Details
Main Authors: Dongrong Yi, Quanjie Li, Lili Pang, Yujia Wang, Yongxin Zhang, Zhaojun Duan, Chen Liang, Shan Cen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Microbiology
Subjects:
antiviral agents
re-emerging viruses
dengue virus
norovirus
RNA-dependent RNA polymerase
virus replication
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01440/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.01440/full

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