Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides

Abstract Etheno (and ethano) derivatives of nucleic acid bases have an extra 5-membered ring attached. These were first noted as wyosine bases in tRNAs. Some were fluorescent, and the development of etheno derivatives of adenosine, cytosine, and guanosine led to the synthesis of fluorescent analogs...

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Bibliographic Details
Main Authors: F. Peter Guengerich, Pratibha P. Ghodke
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Genes and Environment
Subjects:
Online Access:https://doi.org/10.1186/s41021-021-00199-x