Centrally administered pertussis toxin inhibits microglia migration to the spinal cord and prevents dissemination of disease in an EAE mouse model.

Centrally administered pertussis toxin inhibits microglia migration to the spinal cord and prevents dissemination of disease in an EAE mouse model.

Experimental autoimmune encephalomyelitis (EAE) models are important vehicles for studying the effect of infectious elements such as Pertussis toxin (PTx) on disease processes related to acute demyelinating encephalomyelitis (ADEM) or multiple sclerosis (MS). PTx has pleotropic effects on the immune...

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Bibliographic Details
Main Authors: Jun-xiang Yin, Jiang-long Tu, Hao-jie Lin, Fu-dong Shi, Ru-lan Liu, Chong-bo Zhao, Stephen W Coons, Sandra Kuniyoshi, Jiong Shi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2928301?pdf=render

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http://europepmc.org/articles/PMC2928301?pdf=render

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