Inhibition of γ-secretase in adipocytes leads to altered IL-6 secretion and adipose inflammation

Adipocyte-mediated inflammatory signalling has been proposed to alter adipose physiology in obesity and Type 2 diabetes mellitus. Novel targets for alteration of inflammatory signalling are needed to improve obesity-related outcomes. The γ-secretase enzyme complex has been suggested to play a role b...

Full description

Bibliographic Details
Main Authors: David P. Sparling, Nile McCullough, Utpal Pajvani, Mary Beth Humphrey
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Adipocyte
Subjects:
Online Access:http://dx.doi.org/10.1080/21623945.2020.1788235