Natural iminosugar (+)-lentiginosine inhibits ATPase and chaperone activity of hsp90.

Natural iminosugar (+)-lentiginosine inhibits ATPase and chaperone activity of hsp90.

Heat shock protein 90 (Hsp90) is a significant target in the development of rational cancer therapy due to its role at the crossroads of multiple signaling pathways associated with cell proliferation and cell viability. The relevance of Hsp90 as a therapeutic target for numerous diseases states has...

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Bibliographic Details
Main Authors: Fabrizio Dal Piaz, Antonio Vassallo, Maria Giovanna Chini, Franca M Cordero, Francesca Cardona, Claudio Pisano, Giuseppe Bifulco, Nunziatina De Tommasi, Alberto Brandi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3423353?pdf=render

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http://europepmc.org/articles/PMC3423353?pdf=render

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