Different Heat Shock Proteins Bind α-Synuclein With Distinct Mechanisms and Synergistically Prevent Its Amyloid Aggregation

Different Heat Shock Proteins Bind α-Synuclein With Distinct Mechanisms and Synergistically Prevent Its Amyloid Aggregation

α-Synuclein (α-Syn) forms pathological amyloid aggregates deposited in Lewy bodies and Lewy neurites in the brain of Parkinson’s disease (PD) patients. Heat shock proteins (Hsps) are the major components of the cellular chaperone network, which are responsible for preventing proteins from amyloid ag...

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Bibliographic Details
Main Authors: Chunyu Jia, Xiaojuan Ma, Zhenying Liu, Jinge Gu, Xiang Zhang, Dan Li, Shengnan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Neuroscience
Subjects:
Parkinson’s disease
α-syn
amyloid aggregation
heat shock protein
protein homeostasis
synergistic effect
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01124/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.01124/full

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