IL-10 and class 1 histone deacetylases act synergistically and independently on the secretion of proinflammatory mediators in alveolar macrophages.

IL-10 and class 1 histone deacetylases act synergistically and independently on the secretion of proinflammatory mediators in alveolar macrophages.

<h4>Introduction</h4>Anti-inflammatory cytokine IL-10 suppresses pro-inflammatory IL-12b expression after Lipopolysaccharide (LPS) stimulation in colonic macrophages, as part of the innate immunity Toll-Like Receptor (TLR)-NF-κB activation system. This homeostatic mechanism limits excess...

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Bibliographic Details
Main Authors: Brent A Stanfield, Todd Purves, Scott Palmer, Bruce Sullenger, Karen Welty-Wolf, Krista Haines, Suresh Agarwal, George Kasotakis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0245169

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https://doi.org/10.1371/journal.pone.0245169

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