Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes

Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes

Rapidly evolving pathogens such as HIV or influenza can quickly mutate their antigenic profiles, reducing the efficacy of conventional vaccines. Despite this challenge, functionally required epitopes are highly conserved among heterologous viral strains and represent a key vulnerability that could b...

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Bibliographic Details
Main Authors: Murillo Silva, Thao H. Nguyen, Phaethon Philbrook, Matthew Chu, Olivia Sears, Stephen Hatfield, Robert K. Abbott, Garnett Kelsoe, Michail V. Sitkovsky
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Cell Reports
Subjects:
germinal center
immunodominance
subdominant
vaccine
soluble antigen
B cell selection
interclonal competition
B cells
immunoglobulin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717318107

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http://www.sciencedirect.com/science/article/pii/S2211124717318107

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