Insoluble Vascular Amyloid Deposits Trigger Disruption of the Neurovascular Unit in Alzheimer’s Disease Brains

Insoluble Vascular Amyloid Deposits Trigger Disruption of the Neurovascular Unit in Alzheimer’s Disease Brains

Alzheimer’s disease (AD) is a neurodegenerative disease, characterized histopathologically by intra-neuronal tau-related lesions and by the accumulation of amyloid β-peptide (Aβ) in the brain parenchyma and around cerebral blood vessels. According to the vascular hypothesis of AD, an alteration in t...

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Bibliographic Details
Main Authors: Luis O. Soto-Rojas, B. Berenice Campa-Córdoba, Charles R. Harrington, Andrés Salas-Casas, Mario Hernandes-Alejandro, Ignacio Villanueva-Fierro, Marely Bravo-Muñoz, Linda Garcés-Ramírez, Fidel De La Cruz-López, Miguel Ángel Ontiveros-Torres, Goar Gevorkian, Mar Pacheco-Herrero, José Luna-Muñoz
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
fibrillar amyloid
pyroglutamate-modified amyloid-beta peptides
neurovascular unit
blood–brain barrier
caspase-5
Online Access:https://www.mdpi.com/1422-0067/22/7/3654

Internet

https://www.mdpi.com/1422-0067/22/7/3654

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