Directed Evolution of P450 BM3 towards Functionalization of Aromatic O-Heterocycles

Directed Evolution of P450 BM3 towards Functionalization of Aromatic O-Heterocycles

The O-heterocycles, benzo-1,4-dioxane, phthalan, isochroman, 2,3-dihydrobenzofuran, benzofuran, and dibenzofuran are important building blocks with considerable medical application for the production of pharmaceuticals. Cytochrome P450 monooxygenase (P450) <i>Bacillus megaterium</i> 3 (B...

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Bibliographic Details
Main Authors: Gustavo de Almeida Santos, Gaurao V. Dhoke, Mehdi D. Davari, Anna Joëlle Ruff, Ulrich Schwaneberg
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
protein engineering
directed evolution
P450
monooxygenases aromatic heterocycles
hydroxylation
molecular modeling
Online Access:https://www.mdpi.com/1422-0067/20/13/3353

Internet

https://www.mdpi.com/1422-0067/20/13/3353

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