Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model

Abstract Pluripotent stem cell-derived cardiomyocytes show great promise in regenerating the heart after myocardial infarction; however, several uncertainties exist that must be addressed before clinical trials. One practical issue is graft survival following transplantation. Although a pro-survival...

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Bibliographic Details
Main Authors: Tatsuki Ogasawara, Satomi Okano, Hajime Ichimura, Shin Kadota, Yuki Tanaka, Itsunari Minami, Motonari Uesugi, Yuko Wada, Naoto Saito, Kenji Okada, Koichiro Kuwahara, Yuji Shiba
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-09217-x