Zfp148 deficiency causes lung maturation defects and lethality in newborn mice that are rescued by deletion of p53 or antioxidant treatment.

Zfp148 deficiency causes lung maturation defects and lethality in newborn mice that are rescued by deletion of p53 or antioxidant treatment.

The transcription factor Zfp148 (Zbp-89, BFCOL, BERF1, htβ) interacts physically with the tumor suppressor p53 and is implicated in cell cycle control, but the physiological role of Zfp148 remains unknown. Here we show that Zfp148 deficiency leads to respiratory distress and lethality in newborn mic...

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Bibliographic Details
Main Authors: Volkan I Sayin, Anna Nilton, Mohamed X Ibrahim, Pia Ågren, Erik Larsson, Marleen M Petit, Lillemor Mattsson Hultén, Marcus Ståhlman, Bengt R Johansson, Martin O Bergo, Per Lindahl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3566028?pdf=render

Internet

http://europepmc.org/articles/PMC3566028?pdf=render

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