Ceramide as a mediator of non-alcoholic Fatty liver disease and associated atherosclerosis.

Cardiovascular disease (CVD) is a serious comorbidity in nonalcoholic fatty liver disease (NAFLD). Since plasma ceramides are increased in NAFLD and sphingomyelin, a ceramide metabolite, is an independent risk factor for CVD, the role of ceramides in dyslipidemia was assessed using LDLR(-/-) mice, a...

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Bibliographic Details
Main Authors: Takhar Kasumov, Ling Li, Min Li, Kailash Gulshan, John P Kirwan, Xiuli Liu, Stephen Previs, Belinda Willard, Jonathan D Smith, Arthur McCullough
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0126910