From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation

From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation

Proteolysis Targeting Chimeras (PROTACs) are heterobifunctional degraders that specifically eliminate targeted proteins by hijacking the ubiquitin-proteasome system (UPS). This modality has emerged as an orthogonal approach to the use of small-molecule inhibitors for knocking down classic targets an...

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Bibliographic Details
Main Authors: Carlotta Cecchini, Sara Pannilunghi, Sébastien Tardy, Leonardo Scapozza
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Chemistry
Subjects:
proteolysis targeting chimeras
ubiquitin-proteasome system
drug discovery
cell permeability
protein degradation
PROTAC technology
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.672267/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.672267/full

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