Enhancement of Silymarin Anti-fibrotic Effects by Complexation With Hydroxypropyl (HPBCD) and Randomly Methylated (RAMEB) β-Cyclodextrins in a Mouse Model of Liver Fibrosis

Enhancement of Silymarin Anti-fibrotic Effects by Complexation With Hydroxypropyl (HPBCD) and Randomly Methylated (RAMEB) β-Cyclodextrins in a Mouse Model of Liver Fibrosis

Silymarin (Sy) shows limited water solubility and poor oral bioavailability. Water-soluble hydroxypropyl (HPBCD) and randomly methylated (RAMEB) β-cyclodextrins were designed to enhance anti-fibrotic efficiency of silymarin in CCl4-induced liver fibrosis in mice. Experimental fibrosis was induced by...

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Bibliographic Details
Main Authors: Sami Gharbia, Cornel Balta, Hildegard Herman, Marcel Rosu, Judit Váradi, Ildikó Bácskay, Miklós Vecsernyés, Szilvia Gyöngyösi, Ferenc Fenyvesi, Sorina N. Voicu, Miruna S. Stan, Roxana E. Cristian, Anca Dinischiotu, Anca Hermenean
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
silymarin
HPBCD
RAMEB
liver fibrosis
ECM
collagen
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00883/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00883/full

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