Axl kinase drives immune checkpoint and chemokine signalling pathways in lung adenocarcinomas

Axl kinase drives immune checkpoint and chemokine signalling pathways in lung adenocarcinomas

Abstract Axl receptor tyrosine kinase is involved in the growth and metastasis and is an indicator of poor prognosis in several cancers including lung cancers. Although a mitogen-activated protein kinase (MAPK) pathway and an epithelial-to-mesenchymal transition (EMT) program are critical, molecular...

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Bibliographic Details
Main Authors: Yoko Tsukita, Naoya Fujino, Eisaku Miyauchi, Ryoko Saito, Fumiyoshi Fujishima, Koji Itakura, Yorihiko Kyogoku, Koji Okutomo, Mitsuhiro Yamada, Tatsuma Okazaki, Hisatoshi Sugiura, Akira Inoue, Yoshinori Okada, Masakazu Ichinose
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Molecular Cancer
Subjects:
Non-small-cell lung cancer
Axl receptor tyrosine kinase
Immune checkpoint molecules
Chemokine signalling
Global gene expression array
Online Access:http://link.springer.com/article/10.1186/s12943-019-0953-y

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http://link.springer.com/article/10.1186/s12943-019-0953-y

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