Protective LRRK2 R1398H variant enhances GTPase and Wnt signalling activity

Protective LRRK2 R1398H variant enhances GTPase and Wnt signalling activity

Mutations in LRRK2 are a common cause of familial and idiopathic Parkinson’s disease (PD). Recently, the LRRK2 GTPase domain R1398H variant was suggested in genetic studies to confer protection against this condition but mechanistic data supporting this observation is lacking. Here, we present evide...

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Bibliographic Details
Main Authors: Jonathon eNixon-Abell, Daniel C Berwick, Simone eGrannó, Victoria A Spain, Craig eBlackstone, Kirsten eHarvey
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Parkinson’s disease
LRRK2
Wnt signalling
GTPase activity
Protective genetic variant
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00018/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00018/full

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