Increased Dietary Leucine Reduces Doxorubicin-Associated Cardiac Dysfunction in Rats

Increased Dietary Leucine Reduces Doxorubicin-Associated Cardiac Dysfunction in Rats

Cardiotoxicity is one of the most significant adverse effects of the oncologic treatment with doxorubicin, which is responsible for a substantial morbid and mortality. The occurrence of heart failure with ventricular dysfunction may lead to severe cardiomyopathy and ultimately to death. Studies have...

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Bibliographic Details
Main Authors: Thiago M. Fidale, Hanna K. M. Antunes, Luciano Alex dos Santos, Fernanda Rodrigues de Souza, Simone R. Deconte, Francyelle Borges Rosa de Moura, Matheus M. Mantovani, Poliana Rodrigues Alves Duarte, Leonardo Roever, Elmiro S. Resende
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Physiology
Subjects:
doxorubicin
cardiotoxicity
leucine
BCAA
heart failure
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.01042/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.01042/full

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