Protective effect of LNA-anti-miR-132 therapy on liver fibrosis in mice

Protective effect of LNA-anti-miR-132 therapy on liver fibrosis in mice

microRNAs (miRs) are small regulatory RNAs that are frequently deregulated in liver disease. Liver fibrosis is characterized by excessive scarring caused by chronic inflammatory processes. In this study, we determined the functional role of miR-132 using a locked nucleic acid (LNA)-anti-miR approach...

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Bibliographic Details
Main Authors: Fatemeh Momen-Heravi, Donna Catalano, Austin Talis, Gyongyi Szabo, Shashi Bala
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
microRNA-132
liver fibrosis
locked nucleic acid
extracellular vesicles
Kupffer cells
inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121001232

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http://www.sciencedirect.com/science/article/pii/S2162253121001232

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