Increased Endocannabinoid Signaling Reduces Social Motivation in Intact Rats and Does Not Affect Animals Submitted to Early-Life Seizures

Increased Endocannabinoid Signaling Reduces Social Motivation in Intact Rats and Does Not Affect Animals Submitted to Early-Life Seizures

The early life status epilepticus (SE) causes high anxiety and chronic socialization abnormalities, revealed by a low preference for social novelty and deficit in social discrimination. This study investigated the involvement of the endocannabinoid system on the sociability in this model, due to its...

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Bibliographic Details
Main Authors: Fernanda Teixeira Ribeiro, Marcia Ivany Silva de Serro-Azul, Fernanda Beraldo Lorena, Bruna Pascarelli Pedrico do Nascimento, Alexandre José Tavolari Arnold, Geraldo Henrique Lemos Barbosa, Miriam Oliveira Ribeiro, Roberta Monterazzo Cysneiros
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
sociability
seizures
endocannabinoid system
pilocarpine
autism (ASD)
social reward processing
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2020.560423/full

Internet

https://www.frontiersin.org/articles/10.3389/fnbeh.2020.560423/full

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