Gene expression profiling for human iPS-derived motor neurons from sporadic ALS patients reveals a strong association between mitochondrial functions and neurodegeneration

Gene expression profiling for human iPS-derived motor neurons from sporadic ALS patients reveals a strong association between mitochondrial functions and neurodegeneration

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease that leads to widespread motor neuron death, general palsy and respiratory failure. The most prevalent sporadic ALS form is not genetically inherited. Attempts to translate therapeutic strategies have failed because the describ...

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Bibliographic Details
Main Authors: Chrystian Junqueira Alves, Rafael eDariolli, Frederico Mennucci de Haidar Jorge, Matheus Rodrigues Monteiro, Jessica Ruivo Maximino, Roberto Sergio Martins, Bryan Eric Strauss, José Eduardo Krieger, Dagoberto eCallegaro, Gerson eChadi
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Amyotrophic Lateral Sclerosis
Induced Pluripotent Stem Cells
Microarray
Motor neuron differentiation
Sporadic ALS
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00289/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00289/full

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