A translational program that suppresses metabolism to shield the genome

A translational program that suppresses metabolism to shield the genome

Translatome remodelling controls stress-adaptive protein output. Here the authors reveal that in response to stimuli, eIF5A functions as a pH-regulated translation factor that responds to fermentation-induced acidosis affecting cellular metabolism.

Bibliographic Details
Main Authors: Nathan C. Balukoff, J. J. David Ho, Phaedra R. Theodoridis, Miling Wang, Michael Bokros, Lis M. Llanio, Jonathan R. Krieger, Jonathan H. Schatz, Stephen Lee
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19602-2

Internet

https://doi.org/10.1038/s41467-020-19602-2

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