T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks

T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks

Variability within isogenic T cell populations yields heterogeneous ‘local’ signaling responses to shared antigenic stimuli, but responding clones may communicate ‘global’ antigen load through paracrine messengers, such as cytokines. Such coordination of individual cell responses within multicellula...

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Bibliographic Details
Main Authors: Karen E Tkach, Debashis Barik, Guillaume Voisinne, Nicole Malandro, Matthew M Hathorn, Jesse W Cotari, Robert Vogel, Taha Merghoub, Jedd Wolchok, Oleg Krichevsky, Grégoire Altan-Bonnet
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-04-01
Series:eLife
Subjects:
systems immunology
T lymphocyte activation
cytokine
self-organization
feedback regulation
immune monitoring
Online Access:https://elifesciences.org/articles/01944

Internet

https://elifesciences.org/articles/01944

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