Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis

Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis

RAGE signalling is implicated in sepsis. Here the authors use T7 phage display to identify SLP76 as a binding partner for the cytosolic tail of RAGE and provide a reagent that can block this interaction and protect mice from sepsis in a caecal ligation and puncture model.

Bibliographic Details
Main Authors: Zhengzheng Yan, Haihua Luo, Bingyao Xie, Tian Tian, Shan Li, Zhixia Chen, Jinghua Liu, Xuwen Zhao, Liyong Zhang, Yongqiang Deng, Timothy R. Billiar, Yong Jiang
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20577-3

Internet

https://doi.org/10.1038/s41467-020-20577-3

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