mTORC1 and mTORC2 differentially promote natural killer cell development

Natural killer (NK) cells are innate lymphoid cells that are essential for innate and adaptive immunity. Mechanistic target of rapamycin (mTOR) is critical for NK cell development; however, the independent roles of mTORC1 or mTORC2 in regulating this process remain unknown. Ncr1iCre-mediated deletio...

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Bibliographic Details
Main Authors: Chao Yang, Shirng-Wern Tsaih, Angela Lemke, Michael J Flister, Monica S Thakar, Subramaniam Malarkannan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-05-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/35619