Thermostability and excision activity of polymorphic forms of hOGG1

Thermostability and excision activity of polymorphic forms of hOGG1

Abstract Objectives Reactive oxygen species (ROS) oxidize guanine residues in DNA to form 7,8-dihydro-oxo-2′-deoxyguanosine (8oxoG) lesions in the genome. Human 8-oxoguanine glycosylase-1 (hOGG1) recognizes and excises this highly mutagenic species when it is base-paired opposite a cytosine. We soug...

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Bibliographic Details
Main Authors: Kathryn D. Mouzakis, Tiffany Wu, Karl A. Haushalter
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Research Notes
Subjects:
DNA repair
8-Oxoguanine
DNA glycosylase
Mutation
Cancer
Online Access:http://link.springer.com/article/10.1186/s13104-019-4111-9

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http://link.springer.com/article/10.1186/s13104-019-4111-9

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